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Although Aleve is known to exhibit a local anaesthetic effect, how Aleve exerts this effect is not understood fully.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Aleve and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Aleve and M1, respectively.

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Aleve was evaluated in peri- and post-natal studies in rats.
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Aleve has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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Aleve is well absorbed orally with an absolute bioavailability of 75%. Aleve has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Aleve is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
Aleve and M1 elimination half-lives (13 hrs. for Aleve and 19 hrs. for M1).
1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .

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But she was with child, and it ended up that this child was Aleve's.
Aleve is administered as a racemate and both [-] and [+] forms of both Aleve and M1 are detected in the circulation.
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These effects may be worse if you take it with alcohol or certain medicines. Use Aleve with caution.
Aleve had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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For Aleve, the following should be considered:The suitability of Aleve suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
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Aleve has not been shown to cause histamine release. At therapeutic doses, Aleve has no effect on heart rate, left-ventricular function or cardiac index.
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